Anti-CRMP3/FITC抗体

产品编号YB-11821R-FITC

英文名称Anti-CRMP3/FITC

中文名称FITC标记的二氢嘧啶酶相关蛋白3抗体

别    名Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-4; DRP4; ULIP 4; ULIP-4; ULIP4; UNC33 like phosphoprotein 4; UNC33-like phosphoprotein 4.

Anti-CRMP3/FITC抗体

说 明 书100ul  

研究领域细胞生物  神经生物学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Cow,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量62kDa

Anti-CRMP3/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CRMP3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CRMP3/FITC抗体

产品介绍background:

Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.

Function:

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.

Subcellular Location:

Anti-CRMP3/FITC抗体Cytoplasm.

Tissue Specificity:

Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:

Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Database links:

UniProtKB/Swiss-Prot: O14531.2

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.