Anti-CBLN2/FITC抗体

产品编号YB-11815R-FITC

英文名称Anti-CBLN2/FITC

中文名称FITC标记的小脑肽2抗体

别    名A730004O05; Cbln2; CBLN2_HUMAN; Cerebellin 2; Cerebellin 2 precursor; Cerebellin-2; OTTHUMP.

Anti-CBLN2/FITC抗体  

说 明 书100ul  

研究领域细胞生物  神经生物学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量24kDa

细胞定位细胞膜

Anti-CBLN2/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CBLN2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CBLN2/FITC抗体

产品介绍background:

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1.Anti-CBLN2/FITC抗体 Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.

Subunit:

May interact with CBLN1, CBLN3 and CBLN4

Subcellular Location:

Membrane; Single-pass membrane protein

Similarity:

Contains 1 C1q domain.

Database links:

UniProtKB/Swiss-Prot: Q8IUK8.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.