Anti-CLIC6/FITC抗体

产品编号YB-12038R-FITC

英文名称Anti-CLIC6/FITC

中文名称FITC标记的氯离子通道蛋白6抗体

别    名Chloride channel form A; Chloride intracellular channel 6; Chloride intracellular channel protein 6; CLIC1L; Clic6; CLIC6_HUMAN; Parchorin.

Anti-CLIC6/FITC抗体

说 明 书100ul  

研究领域肿瘤  神经生物学  通道蛋白  细胞膜受体  G蛋白偶联受体  新陈代谢  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量73kDa

细胞定位细胞膜

Anti-CLIC6/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CLIC6

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CLIC6/FITC抗体

产品介绍background:

CLIC6 (chloride intracellular channel 6) is believed to play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. The CLIC6 gene is a rare example of large-scale segmental paralogy in which a large (approximately 500 kb) segment on human chromosome (HC) 21 (21q22) is triplicated on HC 1 and HC 6. CLIC6 is also known to interact with dopamine receptors DRD2, DRD3 and DRD4. CLIC6 is primarily expressed in the cytoplasm, however, upon chloride ion efflux from the cell, CLIC6 is translocated to the plasma membrane. CLIC6 has been identified in brain, placenta, pancreas and liver.

Function:

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.

Subunit:

Interacts with dopamine receptors DRD2, DRD3 and DRD4

Subcellular Location:

Cytoplasm. Cell membrane. Predominantly cytoplasmic.Anti-CLIC6/FITC抗体 Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.

Tissue Specificity:

Expressed in brain, placenta, pancreas and liver.

Post-translational modifications:

Phosphorylated.

Similarity:

Belongs to the chloride channel CLIC family.

Contains 1 GST C-terminal domain.

Database links:

UniProtKB/Swiss-Prot: Q96NY7.3

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.