Anti-CUTC/FITC抗体

产品编号YB-11048R-FITC

英文名称Anti-CUTC/FITC

中文名称FITC标记的铜转运蛋白CUTC抗体

别    名CGI 32; CGI32; Copper homeostasis protein cutC homolog; cutC; CutC copper transporter homolog (E. coli); CUTC_HUMAN; RP11-483F11.3.

Anti-CUTC/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  转运蛋白  新陈代谢  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量29kDa

Anti-CUTC/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CUTC

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CUTC/FITC抗体

产品介绍background:

Copper is an essential micronutrient used as a co-factor for several essential enzymes in all living organisms. Due to the high toxicity of copper, its metabolism is tightly regulated and defects in this regulation can cause Menkes (deficiency) or Wilson (accumulation) disease in various tissue. CUTC (cutC copper transporter homolog (E. coli)), also known as CGI-32, is a 273 amino acid protein belonging to the cutC family. CUTC is involved in copper homeostasis and is encoded by a gene located on human chromosome 10, which contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.

Function:

May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Subunit:

Homotetramer.

Subcellular Location:

Cytoplasm. Nucleus. Anti-CUTC/FITC抗体The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.

Tissue Specificity:

Ubiquitous.

Similarity:

Belongs to the CutC family.

Database links:

UniProtKB/Swiss-Prot: Q9NTM9.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.