Anti-CENPL/FITC抗体

产品编号YB13836R-FITC

英文名称Anti-CENPL/FITC

中文名称FITC标记的着丝粒蛋白L抗体

别    名C1orf155; CENP-L; CENPL; CENPL_HUMAN; Centromere protein L; Interphase centromere complex protein 33.

Anti-CENPL/FITC抗体

说 明 书100ul  

研究领域细胞生物  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量39kDa

Anti-CENPL/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human CENPL

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CENPL/FITC抗体

产品介绍background:

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

Function:

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Subcellular Location:

Nucleus. Chromosome > centromere. Anti-CENPL/FITC抗体Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Database links:

Entrez Gene: 91687 Human

Omim: 611503 Human

SwissProt: Q8N0S6 Human

Unigene: 531856 Human

Unigene: 720473 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.