Anti-kappa Opioid receptor/FITC抗体

产品编号YB1094R-FITC

英文名称Anti-kappa Opioid receptor/FITC

中文名称FITC标记的kappa型阿片受体抗体

别    名Kappa type opioid receptor; KOR 1; KOR; Opiate receptor kappa 1; OPRK 1; OPRK; OPRK1; Oprk2; R21; OPRK_HUMAN.  

Anti-kappa Opioid receptor/FITC抗体

说 明 书100ul  

研究领域细胞生物  免疫学  神经生物学  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量43kDa

Anti-kappa Opioid receptor/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human kappa Opioid receptor

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-kappa Opioid receptor/FITC抗体

产品介绍background:

Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors. The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.

Function:

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Subunit:

Interacts with SLC9A3R1. Anti-kappa Opioid receptor/FITC抗体Interacts with GABARAPL1.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Similarity:

Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 4986 Human

Omim: 165196 Human

SwissProt: P41145 Human

Unigene: 106795 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

kappa型阿片受体在人脑和胎盘组织中有分布。κ- 受体参与镇痛 ，且与神经内分泌及免疫调节有关。此外，κ受体也调控喷他佐辛样脊髓镇痛、镇静和瞳孔缩小。κ-阿片受体由380个氨基酸组成，同样属于G蛋白偶联受体家族。