肥大细胞蛋白酶7抗体

规格：1mg/1ml

英文名： PRSS22

别名： Brain specific serine protease 4; BSSP 4; BSSP4; hBSSP 4; MGC9599; Prosemin; Protease serine 22; Protease serine S1 family member 22; PRSS 22; PRSS26; Serine protease 22; Serine protease 26; SP001LA;

分子量： 31kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human PRSS22

交叉反应：Human,

细胞定位：分泌型蛋白

肥大细胞蛋白酶7抗体产品介绍：background: This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008] Function: Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. Subunit: Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin.肥大细胞蛋白酶7抗体 Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6. Subcellular Location: Secreted. Tissue Specificity: Expressed abundantly in the epithelial cells of the airways, including trachea,肥大细胞蛋白酶7抗体 esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland. Similarity: Belongs to the peptidase S1 family. Tryptase subfamily. Contains 1 peptidase S1 domain. Gene ID: 64063 Database links: Entrez Gene: 64063 Human Omim: 609343 Human SwissProt: Q9GZN4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肥大细胞蛋白酶7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  免疫学  信号转导  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid