甲基转移酶cyt-19抗体

规格：1mg/1ml

英文名： CYT 19

别名： 2310045H08Rik; CYT19; Arsenic (+3 oxidation state) methyltransferase; Arsenite methyltransferase; As3mt; AS3MT_HUMAN; C10ORF32; CYT19; Cyt19 protein; Hypothetical protein C10orf32; Methylarsonite meth

分子量： 42kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human CYT 19

交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, hu, mo, rat, cow, hrs, chk, shp, dog, Rb

甲基转移酶cyt-19抗体细胞定位：细胞核

产品介绍：background: Formation of methylated metabolites is a critical step in the metabolism of inorganic arsenic. Arsenite methyltransferase (cyt19) is localized to the cytoplasm and operates in the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate which is reduced to methylarsonite. Methylarsonite acts as a substrate and is converted into a much less toxic compound dimethylarsinate. cyt19 is highly expressed in liver. Inherited variation in 甲基转移酶cyt-19抗体cyt19 may contribute to variation in arsenic metabolism and possibly arsenic-dependent carcinogenesis in humans. Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Subcellular Location:甲基转移酶cyt-19抗体 Cytoplasm. Similarity: Belongs to the methyltransferase superfamily. Gene ID: 57412 Database links: Entrez Gene: 57412 Human Entrez Gene: 57344 Mouse Entrez Gene: 140925 Rat Omim: 611806 Human SwissProt: Q9HBK9 Human SwissProt: Q91WU5 Mouse SwissProt: Q8VHT6 Rat Unigene: 720370 Human Unigene: 28566 Mouse Unigene: 95453 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

甲基转移酶cyt-19抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  信号转导  新陈代谢  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid