鸟氨酸脱羧酶抗体

规格：1mg/1ml

英文名： ODC

别名： Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 2; DCOR_HUMAN; Ornithine decarboxylase 1; Ornithine decarboxylase; Ornithine decarboxylase st

分子量： 51kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human ODC

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,

细胞定位：

鸟氨酸脱羧酶抗体产品介绍：background: Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa. Subunit: Homodimer. Post-translational modifications: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro 鸟氨酸脱羧酶抗体on 4 cysteine residues. Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. Gene ID: 4953 Database links: Entrez Gene: 281365 Cow Entrez Gene: 4953 Human Entrez Gene: 18263 Mouse Entrez Gene: 414408 Pig Entrez Gene: 24609 Rat Omim: 165640 Human SwissProt: P27117 Cow SwissProt: P11926 Human SwissProt: P00860 Mouse SwissProt: P09057 Rat Unigene: 7133 Cow Unigene: 467701 Human 鸟氨酸脱羧酶抗体Unigene: 34102 Mouse Unigene: 874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 鸟氨酸脱羧酶为多胺生物合成途径中的第一个限速酶 (催化合成多胺的第一步反应 ,即催化L -鸟氨酸脱羧生成腐胺 ) ,具有超常转变率和对于刺激的迅速反应性。 多胺广泛存在于生物体的各种细胞和组织中 ,是一种重要的代谢调控物质 ,它可直接与DNA相互作用 ,调节DNA构象 ,并参与RNA及蛋白质的合成 ,与细胞增殖、分化密切相关。经研究表明 ,哺乳动物细胞增殖体现出完全的多胺依赖性。ODC主要存在于胞浆中。

鸟氨酸脱羧酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  信号转导  新陈代谢  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid