组织相容性复合体蛋白2反式激活因子抗体

规格：1mg/1ml

英文名： CIITA

别名： C2TA; C2TA_HUMAN; CIITA; Ciita; CIITA IV; class II major histocompatibility complex transactivator; class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA;

分子量： 123kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human CIITA

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位：细胞核

组织相容性复合体蛋白2反式激活因子抗体产品介绍：background: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome组织相容性复合体蛋白2反式激活因子抗体 type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008] Function: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Subunit: Interacts with ZXDA and ZXDC. Interacts with PML (isoform PML-2). Subcellular Location: Nucleus组织相容性复合体蛋白2反式激活因子抗体. DISEASE: Defects in CIITA are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections. Similarity: Contains 4 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Gene ID: 4261 Database links: Entrez Gene: 4261 Human Omim: 600005 Human SwissProt: P33076 Human Unigene: 701991 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

组织相容性复合体蛋白2反式激活因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  神经生物学  转录调节因子  淋巴细胞  表观遗传学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid