细胞色素C氧化酶17抗体

规格：1mg/1ml

英文名： COX17

别名： COX 17; COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 cytochrome c oxidase assembly homolog; COX17 homolog cytochrome c oxidase assembly protein; COX17_HUMAN; cytochrome c

分子量： 7kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human COX17

交叉反应：Human, Pig,

细胞定位：

细胞色素C氧化酶17抗体产品介绍：background: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene 细胞色素C氧化酶17抗体encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] Function: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Subunit:细胞色素C氧化酶17抗体 Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure. Subcellular Location: Mitochondrion intermembrane space. Tissue Specificity: Ubiquitous. Similarity: Belongs to the COX17 family. Gene ID: 10063 Database links: Entrez Gene: 10063 Human Entrez Gene: 12856 Mouse Entrez Gene: 89786 Rat Omim: 604813 Human SwissProt: Q14061 Human SwissProt: P56394 Mouse Unigene: 534383 Human Unigene: 27396 Mouse Unigene: 19207 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞色素C氧化酶17抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  信号转导  转运蛋白  新陈代谢  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid