二氢乳清酸脱氢酶抗体

规格：1mg/1ml

英文名： DHODH

别名： DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondria

分子量： 43kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human DHODH

交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,

细胞定位：

二氢乳清酸脱氢酶抗体产品介绍：background: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Subcellular Location: Mitochondrion inner membrane. Post-translational modifications: 二氢乳清酸脱氢酶抗体The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration. DISEASE: Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, 二氢乳清酸脱氢酶抗体have been described among a total of around 30 reported cases. Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. Gene ID: 1723 Database links: Entrez Gene: 1723 Human Entrez Gene: 533873 Cow Entrez Gene: 610755 Dog Entrez Gene: 56749 Mouse Entrez Gene: 65156 Rat Entrez Gene: 494065 Zebrafish Omim: 126064 Human SwissProt: Q02127 Human SwissProt: O35435 Mouse SwissProt: Q63707 Rat Unigene: 654427 Human Unigene: 23894 Mouse Unigene: 81502 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

二氢乳清酸脱氢酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  细胞骨架  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid