蛋白赖氨酸-6-氧化酶抗体

规格：1mg/1ml

英文名： LOX

别名： lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase.

分子量： 29kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human LOX

交叉反应：Human, Mouse, Rat, Dog, Pig, Sheep,

细胞定位：

蛋白赖氨酸-6-氧化酶抗体产品介绍：background: The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding蛋白赖氨酸-6-氧化酶抗体 different isoforms have been found for this gene. Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may 蛋白赖氨酸-6-氧化酶抗体have a direct role in tumor suppression. Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. Post-translational modifications: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). Similarity: Belongs to the lysyl oxidase family. Database links: UniProtKB/Swiss-Prot: P28300.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

蛋白赖氨酸-6-氧化酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  心血管  细胞生物  免疫学  信号转导  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid