Fbp5B蛋白抗体

规格：1mg/1ml

英文名： Fbp5B

别名： FBXO43; FBX43_HUMAN; Early mitotic inhibitor 2; EMI2; Endogenous meiotic inhibitor 2; ERP1; F box protein 43; Fbx43.

分子量： 78kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human Fbp5B

交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,

细胞定位：

Fbp5B蛋白抗体产品介绍：background: Members of the F-box protein family, such as Fbp5B, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). Function: Required to establish and maintain the arrest of oocytes at the second Fbp5B蛋白抗体meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20 (By similarity). Post-translational modifications: Phosphorylated on Ser-76, Fbp5B蛋白抗体Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation (Probable). Ubiquitinated in response to calcium, which promotes proteasomal degradation. Similarity: Contains 1 F-box domain. Contains 1 IBR-type zinc finger. Gene ID: 286151 Database links: Entrez Gene: 286151 Human Omim: 609110 Human SwissProt: Q4G163 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fbp5B蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  免疫学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid