角蛋白KRT83抗体

规格：1mg/1ml

英文名： KRT83

别名： KRTHB3; Hair keratin K2.10; Hard keratin, type II, 3; HB 3; HB3; hHb3; K2.10; K83; Keratin 83; Keratin; Keratin, hair, basic, 3; Keratin-83; Krt83; KRT83_HUMAN; KRTHB3; type II cuticular Hb3; Type II

分子量： 54kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human KRT83

交叉反应：Human, Mouse, Rat, Cow, Sheep,

细胞定位：

角蛋白KRT83抗体产品介绍：background: This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012] Function: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla and ends abruptly in 角蛋白KRT83抗体the middle of the cortex. DISEASE: Defects in KRT83 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair,角蛋白KRT83抗体 eyebrows, eyelashes, and nails may also be affected. Similarity: Belongs to the intermediate filament family. Gene ID: 3889 Database links: Entrez Gene: 3889 Human Entrez Gene: 406219 Mouse Entrez Gene: 300246 Rat Omim: 602765 Human SwissProt: P78385 Human SwissProt: Q6IMF0 Mouse Unigene: 720768 Human Unigene: 347934 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

角蛋白KRT83抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid