磷酸化酪氨酸激酶C受体抗体

规格：1mg/1ml

英文名： phospho-TrkC (Tyr820)

别名： TrkC (phospho Y820); p-TrkC (phospho Y820);EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETV6 NTRK3 fusion; GP145 TrkC; gp145(trkC); GP145-TrkC; GP145TrkC; Neurotrophi

分子量： 94kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KKLH conjugated synthesised phosphopeptide derived from huma

交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,

细胞定位：细胞膜

磷酸化酪氨酸激酶C受体抗体产品介绍：background: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do 磷酸化酪氨酸激酶C受体抗体not have identical signaling properties. Subcellular Location: Membrane. Tissue Specificity: Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain. Post-translational modifications: Ligand-mediated auto-phosphorylation. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type 磷酸化酪氨酸激酶C受体抗体(immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain. Gene ID: 4916 Database links: Entrez Gene: 4916 Human Entrez Gene: 18213 Mouse Entrez Gene: 29613 Rat Omim: 191316 Human SwissProt: Q16288 Human SwissProt: Q6VNS1 Mouse SwissProt: Q03351 Rat Unigene: 410969 Human Unigene: 706364 Human Unigene: 33496 Mouse Unigene: 421361 Mouse Unigene: 9963 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷酸化酪氨酸激酶C受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  神经生物学  信号转导  生长因子和激素  细胞膜受体  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid