丝裂原活化蛋白激酶活化的蛋白激酶2/3抗体

规格：1mg/1ml

英文名： MAPKAPK2/3

别名： 3PK; AA960234; MAP kinase activated protein kinase 2; MAP kinase activated protein kinase 3; MAPK activated protein kinase 2; MAPK activated protein kinase 3; MAPKAP kinase 2; MAPKAP kinase 3; MK2; MK

分子量： 44kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human MAPKAPK2

交叉反应：Human, Mouse, Rat,

丝裂原活化蛋白激酶活化的蛋白激酶2/3抗体细胞定位：细胞核 细胞浆

产品介绍：background: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, 丝裂原活化蛋白激酶活化的蛋白激酶2/3抗体phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Expressed in all tissues examined. Database links: Entrez Gene: 7867 Human Entrez Gene: 9261 Human Omim: 602006 Human Omim: 602130 Human 丝裂原活化蛋白激酶活化的蛋白激酶2/3抗体SwissProt: P49137 Human SwissProt: Q16644 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

丝裂原活化蛋白激酶活化的蛋白激酶2/3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  激酶和磷酸酶  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid