肿瘤坏死因子受体超家族成员14抗体

规格：1mg/1ml

英文名： TNFRSF14

别名： HVEM; Tumor necrosis factor receptor superfamily member 14; HVEML; ATAR; CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator A; Herpesvirus entry mediator; Herpesvirus entry

分子量： 27kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human TNFRSF14

交叉反应：Human, Dog, Horse,

细胞定位：细胞膜

肿瘤坏死因子受体超家族成员14抗体产品介绍：background: TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. Function: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because肿瘤坏死因子受体超家族成员14抗体it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. Subunit: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses. Subcellular Location: Membrane; Single-pass type 肿瘤坏死因子受体超家族成员14抗体I membrane protein Tissue Specificity: Widely expressed, with the highest expression in lung, spleen and thymus. Post-translational modifications: N-glycosylated. Similarity: Contains 3 TNFR-Cys repeats. Gene ID: 8764 Database links: Entrez Gene: 8764 Human Entrez Gene: 230979 Mouse Omim: 602746 Human SwissProt: Q92956 Human Unigene: 512898 Human Unigene: 215147 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肿瘤坏死因子受体超家族成员14抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  免疫学  神经生物学  信号转导  细胞凋亡  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid