桥粒芯糖蛋白1

规格：1mg/1ml

英文名： Desmoglein 1

别名： Cadherin family member 4; CDHF4; Desmoglein-1; Desmosomal Glycoprotein 1; DG1; DGI; DSG; DSG1; DSG1_HUMAN; Pemphigus Foliaceus Antigen; PPKS1; SPPK1.

分子量： 108kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human Desmogle

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位：细胞膜

桥粒芯糖蛋白1产品介绍：background: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Subunit: 桥粒芯糖蛋白1Binds to JUP/plakoglobin. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome. Tissue Specificity: Epidermis, tongue, tonsil and esophagus. DISEASE: Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by 桥粒芯糖蛋白1thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Similarity: Contains 4 cadherin domains. Database links: UniProtKB/Swiss-Prot: Q02413.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

桥粒芯糖蛋白1产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  转录调节因子  细胞粘附分子  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid