前列腺素过氧化物合成酶3抗体

规格：1mg/1ml

英文名： Cyclooxygenase 3

别名： Cox-3; Cox 3; Cyclooxygenase 1; Cyclooxygenase 3; Cytochrome c oxidase subunit III; Prostaglandin endoperoxide synthase 3; Ptgs1;COIII; COX3; COX3_HUMAN; COXIII; Cytochrome c oxidase polypeptide III;

分子量： 66kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human Cyclooxy

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

细胞定位：细胞膜

前列腺素过氧化物合成酶3抗体产品介绍：background: Cytochrome c oxidase subunit III, COX3 (also designated COIII, MTCO3 or oxidative phosphorylation (OxPhos) Complex IV, subunit III) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are 前列腺素过氧化物合成酶3抗体encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded. Apoptosis in mammalian cells may be triggered by inhibition of mitochondrial COX. Specifically, reduction of COX3 has been associated with apoptosis and studies have shown that overexpression of COX3 results in a reduction of signals associated with apoptosis. Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Subunit: Homodimer. Subcellular Location: Membrane-associated; Microsomal membrane. Similarity: Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain. Database links: Entrez Gene: 前列腺素过氧化物合成酶3抗体281921 Cow Entrez Gene: 4514 Human Entrez Gene: 17710 Mouse Entrez Gene: 26204 Rat Omim: 516050 Human SwissProt: P00415 Cow SwissProt: P00414 Human SwissProt: P00416 Mouse SwissProt: P05505 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产前列腺素过氧化物合成酶3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  心血管  信号转导  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid