肌细胞增强因子2B抗体

规格：1mg/1ml

英文名： MEF2B

别名： PRDM3; MADS box transcription enhancer factor 2; MDS1 EVI1; Mef2b; MEF2B_HUMAN; MEF-2B; myocyte enhancer factor 2B; myocyte specific enhancer factor 2B; Myocyte-specific enhancer factor 2B; RSRFR2; se

分子量： 39kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human MEF2B

交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,

细胞定位：细胞核

肌细胞增强因子2B抗体产品介绍：background: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins 肌细胞增强因子2B抗体binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes. Function: Transcriptional activator which binds specifically tothe MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerousmuscle-specific genes. Activates transcription via this element.May be involved in muscle-specific and/or growth factor-relatedtranscription. Subunit: Interacts with HDAC7 (By similarity). Heterodimer.Interacts with HDAC9. Subcellular Location: Nucleus. Tissue Specificity: Expressed in skeletal and cardiac muscle and brain. Similarity: 肌细胞增强因子2B抗体Belongs to the MEF2 family. Contains 1 MADS-box domain. Contains 1 Mef2-type DNA-binding domain. Database links: Entrez Gene: 4207 Human Entrez Gene: 17259 Mouse Omim: 600661 Human SwissProt: Q02080 Human SwissProt: O55087 Mouse Unigene: 153629 Human Unigene: 432505 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产肌细胞增强因子2B抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  细胞生物  神经生物学  转录调节因子  表观遗传学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid