Bcl2蛋白修饰因子抗体

规格：1mg/1ml

英文名： Bcl2 modifying factor

别名： Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065.

分子量： 20kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human Bcl2 mod

交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,

细胞定位：

Bcl2蛋白修饰因子抗体产品介绍：background: The BH3-only proteins, which include Blk, Bad, Bik, Hrk, BID, Bim, NOXA, PUMA and Bmf, are proapoptotic members of the Bcl-2 family. Bcl-2 modifying factor (Bmf) is a BH3-only protein that binds prosurvival Bcl-2 family members to initiate apoptosis. Bmf is sequestered to Myosin V motors on Actin in the cytoskeleton by associating with Dynein light chain 2 (DLC2) homodimers. If the cell undergoes loss of attachment (anoikis), the cytoskeleton is disrupted and Bmf is released from DLC2. Bmf then translocates to the mitochondria, where Bcl-2 (an anti-apoptotic family member) is sequestered. The BH3 domain of Bmf facilitatesBcl2蛋白修饰因子抗体 binding to a hydrophobic groove on the surface of Bcl-2. Binding results in a caspase cascade leading to apoptosis. Bmf is widely expressed in tissues such as pancreas, liver and kidney, and in hematopoietic tissues. The gene encoding Bmf maps to chromosome 15q14. Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Subunit: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and Bcl2蛋白修饰因子抗体BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 Tissue Specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Similarity: Belongs to the Bcl-2 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Bcl2蛋白修饰因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  细胞凋亡  细胞骨架  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid