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Bcl2蛋白修饰因子抗体
规格:1mg/1ml
英文名: Bcl2 modifying factor
别名: Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065.
分子量: 20kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Polyclonal
亚型:IgG
纯化方法:affinity purified by Protein A
免疫原:KLH conjugated synthetic peptide derived from human Bcl2 mod
交叉反应:Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位:
Bcl2蛋白修饰因子抗体产品介绍:background: The BH3-only proteins, which include Blk, Bad, Bik, Hrk, BID, Bim, NOXA, PUMA and Bmf, are proapoptotic members of the Bcl-2 family. Bcl-2 modifying factor (Bmf) is a BH3-only protein that binds prosurvival Bcl-2 family members to initiate apoptosis. Bmf is sequestered to Myosin V motors on Actin in the cytoskeleton by associating with Dynein light chain 2 (DLC2) homodimers. If the cell undergoes loss of attachment (anoikis), the cytoskeleton is disrupted and Bmf is released from DLC2. Bmf then translocates to the mitochondria, where Bcl-2 (an anti-apoptotic family member) is sequestered. The BH3 domain of Bmf facilitatesBcl2蛋白修饰因子抗体 binding to a hydrophobic groove on the surface of Bcl-2. Binding results in a caspase cascade leading to apoptosis. Bmf is widely expressed in tissues such as pancreas, liver and kidney, and in hematopoietic tissues. The gene encoding Bmf maps to chromosome 15q14. Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Subunit: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and Bcl2蛋白修饰因子抗体BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 Tissue Specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Similarity: Belongs to the Bcl-2 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Bcl2蛋白修饰因子抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:细胞生物 信号转导 细胞凋亡 细胞骨架
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid
- 询价产品:Bcl2蛋白修饰因子抗体 Bcl2 modifying factor
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