细胞外基质底物反应蛋白1抗体

规格：1mg/1ml

英文名： SPON1

别名： F spondin; F spondin extracellular matrix protein; FSPO; KIAA0762; MGC10724; SPON 1; spondin 1 (f spondin) extracellular matrix protein; Spondin 1; Spondin 1 extracellular matrix protein; Spondin 1 pr

分子量： 86kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

免疫原：KLH conjugated synthetic peptide derived from human SPON1/F

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

细胞定位：细胞外基质 分泌型蛋白

细胞外基质底物反应蛋白1抗体产品介绍：background: SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, 细胞外基质底物反应蛋白1抗体and has also been implicated in inflammatory processes in the nervous system. Subunit: Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal 细胞外基质底物反应蛋白1抗体muscle and ovary. Not expressed in spleen. Similarity: Contains 1 reelin domain. Contains 1 spondin domain. Contains 6 TSP type-1 domains. Database links:   UniProtKB/Swiss-Prot: Q9HCB6.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞外基质底物反应蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  细胞生物  神经生物学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid